The Truth About Cordyceps Sinesis - Part 1

Let's be honest, all sorts of information about Cordyceps is available everywhere, the web is full of information on qualities, benefits, properties and whatever you want to add to sell.

We hide the core value behind the "VALUE" we want to give or offer to our customer.

I honestly believe that the value of the product is no longer in listing properties, mechanisms of action, etc., or let's say it is not only there.

In a digital sales context in the early 2000s, bringing value through key points and emphasizing the benefits of the product or service offered was a new thing and certainly a winning strategy.

in 2021i personally think this model is no longer sustainable, it is no longer sustainable in the digital context in which we find ourselves.

Today we are bombarded with every product or service that should improve our life or make it easier. and if perhaps it is no longer the time to make it simpler or better but only truer?

The digital marketing process has made it possible to create a dense and well-rooted network of services that help achieve a goal. which one? Sales.

The ability to be in control of your business, the sense of being able to achieve financial independence,Ā 

the ability to simplify the sales process without special skills or competences

Platforms, programs, apps, and everything built to entice us to put ourselves in the forefront to sell, to give us the opportunity to generate profit with a click.

this simplicity of execution has allowed each of us to interface directly with a market in complete expansion and to be directly connected and stimulated by it every second of our life.

I think this process has led to a rapid saturation of the digital market in terms of supply.

Let's think about today; How many platforms operate under the model: AMAZON, UBER, NETFLIX, ALIBABA, an infinity.

How many survive emulating the original model? Few.

I am not against this digitization, on the contrary I am its first admirer and I analyze every aspect of it in order to be able to bring a healthy, cohesive, truthful and specifically ethical context.

I am writing these words to make you understand why I speak of truth, the truth of a product is a segment of a corporate and above all commercial truth.

If you love medicinal mushrooms, take a look and tell me what you think.

Today I am talking about cordyceps Sinesis and the differences around this great tonic.Ā 

The Truth about Cordyceps Sinenis :

Ā 

Cordyceps sinensis=hirsutella hepiali Chen et Shen=hirsutella sinensis

These 3 names represent the same thing just with different name, they’ve same DNA construction.

C. sinensisĀ (also termedĀ Ophiocordyceps sinensis) is an ascomycete fungus that possesses a peculiar mode of growth characterized by two main stages; the first stage is characterized by the fungus infecting underground caterpillar larvae in the winter, whereas the second stage is associated with the production of a fruiting body that protrudes from the dead caterpillar's head and grows above the ground during the summer.Ā For this reason,Ā C. sinensisĀ is known as the ā€œcaterpillar fungusā€ or ā€œdong-chong-xia-caoā€ (literally ā€œwinter worm, summer grassā€ in Chinese). The growth of this natural fungus is also unusual due to the fact that it is limited to the Tibetan plateau and southwestern China and it usually grows at or even below the relatively low temperature of 18°C.Ā 

Due to the rarity of naturalĀ C. sinensis, other means of producing this fungus have been investigated. The identity of the anamorph ofĀ C. sinensisĀ has been a topic of considerable controversy in the past.Ā Hirsutella sinensis, which today is widely accepted as the true anamorphic, mycelial stage of naturalĀ C. sinensis, is amenable to culture in vitro and is increasingly used as a health supplement. Studies of the pharmacological properties of HSM have shown that it possesses biological activities similar to that of the wild mushroom. For instance, these activities include reduction of drug-induced leucopenia following kidney transplantation, amelioration of radiation-induced toxicity and stimulation of immune cells in vivo.

Ā 

Cordyceps sinensis and CS_4,are two different planets why?

CS_4 is the most common strain used for commercial products.Ā 

CS, is the English abbreviation of Cordyceps sinensis. Among the strains numbered from 1 to more than 200, the researchers selected the No.4 strain which is the most effective and closest to the wild Cordyceps sinensis, called ā€˜CS-4’. ā€˜CS_ 4’ Compared with other 199 strains, the content of active ingredients was closer to that of Cordyceps sinensis.

CS_ 4. It’s isolated from fresh Cordyceps sinensis, but it may be miscellaneous or even polluted strain. Several molecular biological studies showed that Paecilomyces chinense was not a clonal type of Cordyceps sinensis, and the similarity between the bacteria and the DNA fingerprints of Cordyceps sinensis was very low. By measuring its sequence of rDNA, scientists found that the similarity between Cordyceps sinensis and Paecilomyces chinense was only 72.6%; in addition, some scientists also compared and analyzed the sequence of rDNA its section. The results showed that the genetic differences between Paecilomyces chinense and Cordyceps sinensis in China was large, reaching 0.34, so Paecilomyces sinensis was not asexual of ā€˜Cordyceps sinensis’.

CS_4 has better effective ingredients than other Cordyceps strain, but it's DNA cannot replace Cordyceps sinensis. CS_4 is a strain taken from Cordyceps Sinesis DNA and extracted through a process called " liquid fermentation". This is the easiest and most affordable way to extract Cordyceps Sinesis From the Original DNA.

The natural and wild ā€˜Cordyceps sinensis’ is rich in a variety of high-quality effective ingredients. However, due to its harsh growth environment and conditions, it is difficult to collect, and the High demand has led to drammatic exploitation of resources and a shortage. Therefore, China has issued a protection policy, explicitly forbidding individuals and enterprises to directly use ā€˜natural and wild Cordyceps sinensis’ as raw materials for health food. At the same time, if the ā€˜natural and wild Cordyceps sinensis’ is not scientifically extracted, it will not be able to fully release the effective components in the body, and the human body can not fully absorb it.

What is Hirsutella Hepiali Chen et chen ? and why we ONLY use this strain

After a long period of research, a large number of experiments and the firm determination of the third-party authority, ā€˜Hirsutella hepiali chen et shen’ has been considered the only asexual strain of ā€˜natural and wild Cordyceps sinensis’, and it has complete DNA genetic information same as ā€˜Cordyceps sinensis’.

Hirsutella sinensisĀ has, by far, the highest number of published reports than other reported anamorphs. This is a reflection of many studies which have confirmedĀ H. sinensisĀ as the true anamorph ofĀ O. sinensisĀ [5,Ā 6,Ā 15,Ā 19,Ā 20]. This is also a clear indication that there is now much more research interest onĀ H. sinensisĀ than the other isolates.

In other words, ā€˜Hirsutella hepiali chen et shen’ it can be consider the closest strain toā€˜Cordyceps sinensis’.

Ā At the same time, about 200 kinds of mixed bacteria can be isolated from ā€˜Cordyceps sinensis’, but onlyĀ  "hirsutella hepiali chen et shen" can grow into "Cordyceps sinensis"!

The DNA of the other bacteria can't match with Cordyceps sinensis!

In the laboratory, the high-quality ā€˜Hirsutella hepiali chen et shen’ strain was breed into Mycelium of Hirsutella hepiali chen et shen’.

ā€˜Cordyceps sinensis’(that’s Cordyceps sinensis (Berk.) Sacc), which is hirsutella hepiali Chen et shen, has a high similarity of DNA structure, up to 99.46%.Ā 

  • The most authentic "Cordyceps sinensis (Berk.) Sacc" is ā€˜hirsutella hepiali chen et shen’, also known as "hirsutella bat moth", which is an asexual fungus of ā€˜Cordyceps sinensis’
  • Since 2000, PhD.Yao Yijian from the Royal Botanical Garden of the United Kingdom , led the members of the research team to the Qinghai Tibet plateau many times. After verification, PhD.Yao Yijian and others scientists confirmed that the ā€˜Hirsutella hepiali chen et shen’, and ā€˜hirsutella sinensis’ are exactly the anamorph. That’s to say, they’re pretty real ā€˜cordyceps sinensis’. Meanwhile Paecilomyces chinense(CS_4) and the Trichothecium bat moth are not consdered Cordyceps sinensis.Ā 

Ā 

WHY YOU SHOULD THINK TWICE BEFORE BUYINGĀ  CS_4 STRAIN CORDYCEPS MYCELIUM!!

The substrate where this strain is cultivated is soybean at first, but with high risk that genetically modified soybean is used, or that soya allergies may appear.Ā 

Have you ever experience mild side effects taking cordyceps? if so it is most likely that your cordyceps was made with this fast and easy process

WHAT WE USED INSTEAD, AND WHY YOU SHOULD GIVE IT A GO!

We use a patented processing method of cordyceps sinensis mycelium, with the following steps: cultivating a Hirsutella hepiali Chen et Shen strain to obtain mycelium, conducting ultrasonic extraction by using 30-50 wt% of ethyl alcohol, filtering by using a membrane with a molecular weight of 2000-4000 Daltons, centrifugalizing, discarding a precipitate, extracting a supernatant, and cooling and drying to obtain a concentrated freeze-dried mycelium powder.

Our Method has been proven to be 12 times more concentrated than Commercial Strain Cs-4 Mycelium and other type of Strain used for the production of this type of products.

End Part 1Ā 

Ā 

References
Ā 

  1. D. H. Jennings and G. Lysek,Ā Fungal Biology: Understanding the Fungal Lifestyle, BIOS Scientific Publishers, New York, NY, USA, 2nd edition, 1999.
  2. C. S. Chen, R. S. Hseu, and C. T. Huang, ā€œQuality control ofĀ Cordyceps sinensisĀ teleomorph, anamorph, and its products,ā€ inĀ Quality Control of Herbal Medicines and Related Areas, Y. Shoyama, Ed., InTech, 2011.View at:Ā Google Scholar
  3. J. C. Holliday, P. Cleaver, M. Loomis-Powers, and D. Patel, ā€œAnalysis of quality and techniques for hybridization of medicinal fungusĀ Cordyceps sinensisĀ (Berk.) Sacc. (Ascomycetes),ā€Ā International Journal of Medicinal Mushrooms, vol. 6, no. 2, pp. 151–164, 2004.View at:Ā Google Scholar
  4. J.-S. Zhu, Y. Yao, W. Chen, T. Zheng, J. Lu, and Y. Guo, ā€œMolecular co-existence ofĀ Paecilomyces hepialiĀ andĀ Hirsutella sinensisĀ in caterpillar and fruiting bodies ofĀ Cordyceps sinensis,ā€Ā The FASEB Journal, vol. 21, article 841.7, 2007.View at:Ā Google Scholar
  5. Y.-Q. Chen, N. Wang, L.-H. Qu, T.-H. Li, and W.-M. Zhang, ā€œDetermination of the anamorph ofĀ Cordyceps sinensisĀ inferred from the analysis of the ribosomal DNA internal transcribed spacers and 5.8S rDNA,ā€Ā Biochemical Systematics and Ecology, vol. 29, no. 6, pp. 597–607, 2001.View at:Ā Publisher SiteĀ |Ā Google Scholar
  6. J.-L. Yang, W. Xiao, H.-X. He et al., ā€œMolecular phylogenetic analysis ofĀ Paecilomyces hepialiĀ andĀ Cordyceps sinensis,ā€Ā Yaoxue Xuebao, vol. 43, no. 4, pp. 421–426, 2008.View at:Ā Google Scholar
  7. C. Li, Z. Li, M. Fan et al., ā€œThe composition ofĀ Hirsutella sinensis, anamorph of Cordyceps sinensis,ā€Ā Journal of Food Composition and Analysis, vol. 19, no. 8, pp. 800–805, 2006.View at:Ā Publisher SiteĀ |Ā Google Scholar
  8. Y. Jiang and Y.-J. Yao, ā€œNames related toĀ Cordyceps sinensisĀ anamorph,ā€Ā Mycotaxon, vol. 84, pp. 245–254, 2004.View at:Ā Google Scholar
  9. Y. Kobayasi, ā€œKey to taxa of the generaĀ CordycepsĀ andĀ Torrubiella,ā€Ā Transactions of the Mycological Society of Japan, vol. 23, pp. 329–364, 1982.View at:Ā Google Scholar
  10. Y. Q. Chen, S. R. Xiao, and Z. Y. Shi, ā€œPaecilomyces sinensisĀ sp. nov. and its connection withĀ Cordyceps sinensis,ā€Ā Acta Mycologica Sinica, vol. 3, no. 1, pp. 24–28, 1984.View at:Ā Google Scholar
  11. Z.-Q. Li and Y.-H. Sun, ā€œA new species ofĀ Scytalidium-Scytalidium helpiali,ā€Ā Acta Mycologica Sinica, vol. 7, pp. 23–28, 1988.View at:Ā Google Scholar
  12. C. L. Li, ā€œA study ofĀ Typocladium sinensisĀ C.L.Li. sp. nov and cyclosporin production,ā€Ā Acta Mycologica Sinica, vol. 7, no. 2, pp. 93–98, 1998.View at:Ā Google Scholar
  13. Z.-Q. Liang, ā€œA new species ofĀ ChrysosporiumĀ fromĀ Cordyceps sinensisĀ (Berk.) Sacc,ā€Ā Acta Mycologica Sinica, vol. 10, pp. 50–56, 1991.View at:Ā Google Scholar
  14. G.-H. Sung, N. L. Hywel-Jones, J.-M. Sung, J. J. Luangsa-ard, B. Shrestha, and J. W. Spatafora, ā€œPhylogenetic classification ofĀ CordycepsĀ and the clavicipitaceous fungi,ā€Ā Studies in Mycology, vol. 57, no. 1, pp. 5–59, 2007.View at:Ā Publisher SiteĀ |Ā Google Scholar
  15. Z.-Y. Liu, Y.-J. Yao, A.-Y. Liu, D. N. Pegler, and M. W. Chase, ā€œMolecular evidence for the anamorph-teleomorph connection in Cordyceps sinensis,ā€Ā Mycological Research, vol. 105, no. 7, pp. 827–832, 2001.View at:Ā Publisher SiteĀ |Ā Google Scholar
  16. X. J. Liu, Y. L. Guo, Y. X. Yu, and W. Zeng, ā€œIsolation and identification of the anamorphic stage ofĀ Cordyceps sinensisĀ ( Berk.) Sacc,ā€Ā Acta Mycologica Sinica, vol. 8, no. 1, pp. 35–40, 1989.View at:Ā Google Scholar
  17. X.-C. Yin and L.-Y. Shen, ā€œThe conidial state of Cordyceps sinensis (Berk.) Sacc.Ā Synnematium sinenseĀ Yin et Shen, sp. nov,ā€Ā Acta Biologica Plateau Sinica, vol. 9, pp. 1–5, 1990.View at:Ā Google Scholar
  18. N.-Y. Shen, ā€œBrief account of research onĀ Cordyceps sinensis,ā€Ā Medicinal Fungi, vol. 1-2, pp. 85–88, 1983.View at:Ā Google Scholar
  19. Z. Q. Liang, ā€œAnamorphs ofĀ CordycepsĀ and determination of the relationship between anamorph and teleomorph,ā€Ā Journal of Southwest Agriculture, vol. 4, pp. 1–8, 1991.View at:Ā Google Scholar
  20. Z.-Y. Liu, Z.-Q. Liang, A.-Y. Liu, Y.-J. Yao, K. D. Hyde, and Z.-N. Yu, ā€œMolecular evidence for teleomorph-anamorph connections in Cordyceps based on its-5.8S rDNA sequences,ā€Ā Mycological Research, vol. 106, no. 9, pp. 1100–1108, 2002.View at:Ā Publisher SiteĀ |Ā Google Scholar
  21. T.-H. Hsu, L.-H. Shiao, C. Hsieh, and D.-M. Chang, ā€œA comparison of the chemical composition and bioactive ingredients of the Chinese medicinal mushroom DongChongXiaCao, its counterfeit and mimic, and fermented mycelium ofĀ Cordyceps sinensis,ā€Ā Food Chemistry, vol. 78, no. 4, pp. 463–469, 2002.View at:Ā Publisher SiteĀ |Ā Google Scholar
  22. G. S. Barseghyan, J. C. Holliday, T. C. Price, L. M. Madison, and S. P. Wasser, ā€œGrowth and cultural-morphological characteristics of vegetative mycelia of medicinal caterpillar fungusĀ Ophiocordyceps sinensisĀ G.H. Sung et al. (Ascomycetes) isolates from tibetan plateau (P.R. China),ā€Ā International Journal of Medicinal Mushrooms, vol. 13, no. 6, pp. 565–581, 2011.View at:Ā Publisher SiteĀ |Ā Google Scholar
  23. R. T. Hanlin, ā€œMicrocycle conidiation: a review,ā€Ā Mycoscience, vol. 35, no. 1, pp. 113–123, 1994.View at:Ā Publisher SiteĀ |Ā Google Scholar
  24. Y. Ito and T. Hirano, ā€œThe determination of the partial 18 S ribosomal DNA sequences of Cordyceps species,ā€Ā Letters in Applied Microbiology, vol. 25, no. 4, pp. 239–242, 1997.View at:Ā Publisher SiteĀ |Ā Google Scholar
  25. A. E. Glenn, C. W. Bacon, R. Price, and R. T. Hanlin, ā€œMolecular phylogeny of Acremonium and its taxonomic implications,ā€Ā Mycologia, vol. 88, no. 3, pp. 369–383, 1996.View at:Ā Publisher SiteĀ |Ā Google Scholar
  26. I. L. Gonzalez, J. E. Sylvester, T. F. Smith, D. Stambolian, and R. D. Schmickel, ā€œRibosomal RNA gene sequences and hominoid phylogeny,ā€Ā Molecular Biology and Evolution, vol. 7, no. 3, pp. 203–219, 1990.View at:Ā Google Scholar
  27. S. B. Lee and J. W. Taylor, ā€œPhylogeny of five fungus-like protoctistanĀ phytophthoraĀ species, inferred from the internal transcribed spacers of ribosomal DNA,ā€Ā Molecular Biology and Evolution, vol. 9, no. 4, pp. 636–653, 1992.View at:Ā Google Scholar
  28. V. M. Morales, L. E. Pelcher, and J. L. Taylor, ā€œComparison of the 5.8s rDNA and internal transcribed spacer sequences of isolates ofĀ Leptosphaeria maculansĀ from different pathogenicity groups,ā€Ā Current Genetics, vol. 23, no. 5-6, pp. 490–495, 1993.View at:Ā Publisher SiteĀ |Ā Google Scholar
  29. L. H. Qu and Y. Q. Chen, ā€œKey to molecular taxonomy—principles and methods,ā€Ā Acta Scientiarum Naturalium Universitatis Sunyatseni, vol. 38, no. 1, pp. 1–7, 1999.View at:Ā Google Scholar
  30. D. S. Hibbett, ā€œRibosomal RNA and fungal system,ā€Ā Transactions of the Mycological Society of Japan, vol. 33, pp. 533–556, 1992.View at:Ā Google Scholar
  31. N. Nikoh and T. Fukatsu, ā€œInterkingdom host jumping underground: phylogenetic analysis of entomoparasitic fungi of the genus Cordyceps,ā€Ā Molecular Biology and Evolution, vol. 17, no. 4, pp. 629–638, 2000.View at:Ā Publisher SiteĀ |Ā Google Scholar
  32. C. S. Chen and R. S. Hseu, ā€œDifferentiation ofĀ Cordyceps sinensisĀ (Berk.) Sacc. specimen using restriction fragment length polymorphism of 18S rRNA gene,ā€Ā Journal of the Chinese Agricultural Chemical Society, vol. 37, pp. 533–555, 1999.View at:Ā Google Scholar
  33. J. Holliday and M. Cleaver, ā€œOn the Trail of the Yak: AncientĀ CordycepsĀ in the Modern World,ā€ 2004,Ā http://www.alohamedicinals.com/Cordy_Article.pdf.View at:Ā Google Scholar
  34. Aloha Medicinals, ā€œCordycepsĀ History and Cultivation,ā€Ā http://www.alohamedicinals.com/cordyceps.html#.U5v1V3bm7XU.View at:Ā Google Scholar
  35. S. Zhang, Y.-J. Zhang, X.-Z. Liu, H. Zhang, and D.-S. Liu, ā€œOn the reliability of DNA sequences ofĀ Ophiocordyceps sinensisĀ in public databases,ā€Ā Journal of Industrial Microbiology and Biotechnology, vol. 40, no. 3-4, pp. 365–378, 2013.View at:Ā Publisher SiteĀ |Ā Google Scholar
  36. D. L. Hawksworth, ā€œA new dawn for the naming of fungi: impacts of decisions made in Melbourne in July 2011 on the future publication and regulation of fungal names,ā€Ā MycoKeys, vol. 1, pp. 7–20, 2011.View at:Ā Google Scholar
  37. H. C. Lo, C. Hsieh, F. Y. Lin, and T. H. Hsu, ā€œA systematic review of the mysterious caterpillar fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (Dōng Chóng XiĆ  CĒŽo) and related bioactive ingredients,ā€Ā Journal of Traditional and Complementary Medicine, vol. 3, no. 1, pp. 16–32, 2013.View at:Ā Publisher SiteĀ |Ā Google Scholar

Ā 

Ā